As the most dominant means to tackle reservoir leakage, anti-seepage curtain has been broadly used in the construction of hydropower projects. In recent years, many hydropower projects have been built in southwest China where carbonate strata develops widely with complex karst conditions, giving rise to frequent grouting abnormalities such as excessive amount and leakage in construction period of anti-seepage curtain. As a giant hydropower station built in typical carbonate rock area, Wudongde hydropower station has a maximum dam height of 270 m and a largest water retaining head of about 160 m, with large curtain scale, high water head, and complex geological conditions. In view of the local grouting abnormality at 850 m grouting adit on the left bank of anti-seepage curtain of the dam, we propose to employ a “3D geological information visualization of grouting engineering analysis system (GEAS 3D)” for examining the scope of abnormal area, the engineering geological characteristics and grouting characteristics in association with traditional means such as grouting hole, special investigation hole, construction branch hole and geophysical detection so as to provide basis for targeted treatment. This paper offers a solution for grouting anomaly comprehensive analysis based on “geological BIM plus grouting information” analysis management platform, which can be used for reference for similar projects.