Comparative study was carried out on the performances of roller compacted concrete (RCC) doped respectively with fly ash, natural pozzolana, and both fly ash and pozzolana. Compared with RCC with fly ash, more cementitious material is used in RCC with natural pozzolana when the water-binder ratio and the contents of wate-reducing agent are the same, resulting in much shorter setting time. And the strength active effect in later stage is lower with larger shrinkage deformation and higher adiabatic temperature rise. The research results provide data support for the utilization of natural pozzolana as a mixture in RCC in southwest China.