According to measured data of water level and water quality at typical sites of Huayang River and Lake Group, we analyzed the influences of spatial and temporal changes of water level on water quality indicators and the correlation between water level and water quality using the Spearman method. Results demonstrated that affected by the incoming water quality of the Yangtze River, the water quality of Huyang River and Lake Group was inferior in the west while superior in the east. In interannual scale, the water quality of Longgan Lake, Huanghu Lake, Bohu Lake and Daguan Lake fluctuated from 2015 to 2018, and particularly in 2018, the water quality of Longgan Lake, Huanghu Lake and Bohu Lake were inferior; in annual scale, the pollutant concentration index of each lake was larger in dry season than that in wet season. In addition, water level fluctuation is negatively correlated with the concentration of TN, TP and COD. The average correlation coefficient is about -0.43, -0.41, -0.09, respectively, and the absolute values are all smaller than 0.5.