Abstract: The mid-route of South-to-North Water Diversion Project has many control buildings and complex geological conditions as well as quite different geographical and meteorological conditions along the long line. The design, construction and operation of the project is faced with many technically difficult hydraulics problems. Through decades of research, the Yangtze River Scientific Research Institute has obtained fruitful research results, some of which were applied to the project successfully. In this paper, we expound and summarize several major achievements including canal roughness issues, sluice discharge formula, type of the yellow river crossing tunnel and its hydraulic characteristics, emergency dispatch, and water diversion in winter. It provides technical support for the operation of the middle route and also could be regarded as reference for the design of similar projects.